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Promethazine can cause side effects that may impair your thinking or reactionsBe careful if you drive or do anything that requires you to be awake and alertAvoid drinking alcoholwhich can increase some of the side effects of promethazineThere are many other medicines that can interact with promethazineTell your doctor about all the prescription and over-the-counter medications you useThis includes vitaminsmineralsherbal productsand drugs prescribed by other doctorsDo not start using a new medication without telling your doctorKeep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

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CNS DepressantsPromethazine hydrochloride tablets may increaseprolongor intensify the sedative action of other central-nervous-system depressantssuch as alcoholsedatives/hypnoticsincluding barbituratesnarcoticsnarcotic analgesicsgeneral anestheticstricyclic anti-depressantsand tranquilizersthereforesuch agents should be avoided or administered in reduced dosage to patients receiving promethazine HClWhen given concomitantly with promethazine hydrochloride tabletsthe dose of barbiturates should be reduced by at least one-halfand the dose of narcotics should be reduced by one-quarter to one-halfDosage must be individualizedExcessive amounts of promethazine HClpromethazine hydrochloriderelative to a narcotic may lead to restlessness and motor hyperactivity in the patient with painthese symptoms usually disappear with adequate control of the pain.

Promethazine should not be given to a child younger than 2 years oldPromethazine can cause severe breathing problems or death in very young childrenCarefully follow your doctor’s instructions when giving this medicine to a child of any age.

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